|
cervical cancer
|
|
0.720 |
GeneticVariation
|
BEFREE |
<i>Conclusion.</i> HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.
|
30009173 |
2018 |
|
Malignant tumor of cervix
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>Conclusion.</i> HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.
|
30009173 |
2018 |
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>Conclusion.</i> HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.
|
30009173 |
2018 |
|
Rheumatoid Arthritis
|
|
0.710 |
GeneticVariation
|
BEFREE |
Allele A of rs9277535 in HLA-DP correlated to increased risk of RA and elevated serum anti-CCP level.
|
29476350 |
2018 |
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This is the first study demonstrating the significant associations of SNP rs3077, rs9277535 and rs7574865 and the haplotypes in the HLA gene with the risk of IgAN in a Southwest Chinese population.
|
29467950 |
2018 |
|
Complete atrioventricular block
|
|
0.040 |
GeneticVariation
|
BEFREE |
rs1883832 serves as a valuable predictive factor for CHB patients with HBeAg seroconversion. rs9277535 at HLA-DP might also be a valuable predictive factor for CHB patients with HBeAg-negative, however, further verifications are recommended due to study limitations.
|
29451182 |
2018 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated.
|
29300980 |
2018 |
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
The HLA-DQ rs7453920 and -DP rs9277535 mutations were significantly associated with HCV infection susceptibility and chronicity, respectively.
|
29212520 |
2017 |
|
Occult chronic type B viral hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The combination of haplotype markers (TGA for rs3077-rs3135021-rs9277535) was associated with increased risk of OBI (OR = 4.90, 95%CI = 1.12-21.52 p = 0.038).
|
29061159 |
2017 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine.
|
28882445 |
2017 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
No significant correlation was shown in HLA-DP rs3077 and rs9277535 with HBV infection or liver function recovery (P < .05).Our study concluded that HLA-DP (rs3077 and rs9277535) and HLA-DQ (rs7453920) were not significantly associated with HBV recurrence or HBV susceptibility, but HLA-DQ rs7453920 was related to prognosis of liver transplant recipients.
|
28640108 |
2017 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population.
|
28613373 |
2017 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results showed that rs9277535 allele frequency is associated with HBV infection in the Turkish subjects examined (P=0.048).
|
28119119 |
2017 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
BEFREE |
In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents.
|
28119119 |
2017 |
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, HLA-DP polymorphisms (rs3077 and rs9277535) were associated with SLE susceptibility and the levels of some inflammatory cytokines in SLE patients.
|
28094303 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, HLA-DP polymorphisms (rs3077 and rs9277535) were associated with SLE susceptibility and the levels of some inflammatory cytokines in SLE patients.
|
28094303 |
2017 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results of logistic regression analyses showed that the HLA-DPB1 rs9277535 variants were associated with a reduced risk of persistent HBV infection (odds ratio [OR] 0.70, 95% confidence interval [95% CI] 0.52-0.96, P=0.026, additive genetic model; OR 0.60, 95% CI 0.38-0.96, P=0.033, dominant genetic model).
|
27051043 |
2016 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Association between rs9277535 and HCC susceptibility was examined in five separate comparisons that contained 2017 cases and 3930 carriers.
|
26634522 |
2015 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that rs3077 and rs9277535 in HLA-DP significantly decreased HBV infection risks and increased HBV clearance possibility in a dose-dependent manner.
|
26462556 |
2015 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
We identified 76 SNPs and 5 LD blocks in HLA-DP/DQ clusters that are significantly associated with HBV infection, with the smallest P value being 3.88 × 10(-18) for rs9277535 in HLA-DPB1.
|
26197724 |
2015 |
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
Complete atrioventricular block
|
|
0.040 |
GeneticVariation
|
BEFREE |
Additionally, we validated seven of eight previously reported CHB susceptibility loci (rs3130542 at HLA-C, rs1419881 at TCF19, rs652888 at EHMT2, rs2856718 at HLA-DQB1, rs7453920 at HLA-DQB2, rs3077 at HLA-DPA1, and rs9277535 at HLA-DPA2, which are all located in the HLA region, 9.84 × 10(-71) ≤ Pmeta ≤ 9.92 × 10(-7) ).
|
25802187 |
2015 |
|
Hepatitis B
|
|
0.900 |
GeneticVariation
|
BEFREE |
The combination of rs9277535 in HLA and rs16944 in IL1B was the best model to predict chronic HBV infection (testing accuracy = 0.6040, P = 0.0010, cross-validation consistency = 10/10).
|
25469587 |
2015 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
However, the experiment showed that HLA-DP rs3077, rs9277535 and rs7453920 did not associate with HCC development (dominant model, rs3077, OR = 0.86, 95%CI = 0.62-1.18; rs9277535, OR = 0.94, 95%CI = 0.68-1.30; rs7453920, OR = 0.75, 95%CI = 0.44-1.27).
|
25365208 |
2014 |